Title
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Synthesis and studies of phenothiazine based AIE fluorogens
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Author
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Abstract
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Phenothiazine based AIE fluorogens linked to phenyl and tetraphenylethylene groups are reported. The N-butylphenothiazine and N-phenylphenothiazine have been substituted at 3,7-positions with phenyl or tetraphenylethylene (TPE) groups. All the target molecules have been characterized by 1H and 13C NMR, and mass spectrometry. The UV-Vis absorption, fluorescence and aggregation induced emission (AIE) properties of target molecules have been studied. Typically, the phenyl and TPE substituted phenothiazine molecules exhibit strong absorption band (λabs = 331 to 358 nm) in THF. Also, weak emission is observed in THF (λem = 405 to 531 nm) for these compounds; due to AIE phenomenon in water/THF mixture (fw≥70%) the emission intensity is drastically enhanced upon aggregation. Bioimaging studies in A549 cells reveal cytoplasmic distribution of the 3,7-diphenylphenothiazine derivatives with ≥ 90% cell viability. |
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Language
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English
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Source (journal)
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Indian journal of chemistry: section B, organic chemistry, including medicinal chemistry. - New Delhi
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Publication
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New Delhi
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2019
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ISSN
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0376-4699
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Volume/pages
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58
:2
(2019)
, p. 238-246
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ISI
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000467888700013
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