Publication
Title
Synthesis and studies of phenothiazine based AIE fluorogens
Author
Abstract
Phenothiazine based AIE fluorogens linked to phenyl and tetraphenylethylene groups are reported. The N-butylphenothiazine and N-phenylphenothiazine have been substituted at 3,7-positions with phenyl or tetraphenylethylene (TPE) groups. All the target molecules have been characterized by 1H and 13C NMR, and mass spectrometry. The UV-Vis absorption, fluorescence and aggregation induced emission (AIE) properties of target molecules have been studied. Typically, the phenyl and TPE substituted phenothiazine molecules exhibit strong absorption band (λabs = 331 to 358 nm) in THF. Also, weak emission is observed in THF (λem = 405 to 531 nm) for these compounds; due to AIE phenomenon in water/THF mixture (fw≥70%) the emission intensity is drastically enhanced upon aggregation. Bioimaging studies in A549 cells reveal cytoplasmic distribution of the 3,7-diphenylphenothiazine derivatives with ≥ 90% cell viability.
Language
English
Source (journal)
Indian journal of chemistry: section B, organic chemistry, including medicinal chemistry. - New Delhi
Publication
New Delhi : 2019
ISSN
0376-4699
Volume/pages
58 :2 (2019) , p. 238-246
ISI
000467888700013
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identifier
Creation 20.10.2023
Last edited 21.10.2023
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