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Title
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Surveillance on methicillin sensitive Staphylococcus aureus colonization and infection in a neonatal intensive care unit
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Author
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Abstract
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| Background: Methicillin sensitive Staphylococcus aureus (MSSA) infection is a significant health concern in neonatal intensive care units (NICUs). Bacterial colonization increases the risk of subsequent infection, leading to morbidity and mortality. Aim: To report the findings of a retrospective cohort study on the surveillance of MSSA colonization and infection in NICU patients. Methods: The weekly microbial surveillance results for MSSA colonization in the throat, nose, anus, and groin, as well as invasive and non-invasive MSSA infections, were analysed from November 2020 to June 2022. The MSSA infection and colonization risk were compared after adjustment for confounders by stepwise logistic regression analysis. Findings: Three hundred and eighty-three neonates were screened; 42.8% (N=164) were MSSA colonized. Significant risk factors for MSSA colonization were length of stay, vaginal delivery and extreme low gestational age <28 weeks [ELGAN] (all P < 0.05). The surveillance detected 38 (9.9%) mild MSSA infections and 11 (2.9%) invasive MSSA infections. Neonatal colonization with MSSA is a major risk factor for MSSA infection overall (29.3% in colonized/infected vs. 70.7% colonized/not-infected and 0.5% in not-colonized/infected vs. 99.5% in not-colonized/not-infected infants) and invasive MSSA infections (6.1% in colonized/infected vs. 93.9% in colonized/not-infected and 0.5% in non-colonized/infected vs. 99.5% not-colonized/not-infected infants). Also, extreme low birth weight (<1000g), ELGAN and invasive ventilation were significant risk factor for MSSA infections (all, P < 0.05). Conclusions: The link between postnatal MSSA colonization and subsequent MSSA infection offers possibilities for prevention. Additional research is needed to explore the association between vaginal birth and the pathogenesis of neonatal MSSA colonization. |
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Language
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English
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Source (journal)
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The journal of hospital infection. - New York, N.Y.
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Publication
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New York, N.Y.
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2024
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ISSN
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0195-6701
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DOI
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10.1016/J.JHIN.2023.10.003
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Volume/pages
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143
(2024)
, p. 195-202
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ISI
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001164097600001
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Pubmed ID
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37858807
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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