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Title
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A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa
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Author
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Abstract
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| Invasive non-typhoidal Salmonella (iNTS) disease manifesting as bloodstream infection with high mortality is responsible for a huge public health burden in sub-Saharan Africa. Salmonella enterica serovar Typhimurium ( S . Typhimurium) is the main cause of iNTS disease in Africa. By analysing whole genome sequence data from 1303 S . Typhimurium isolates originating from 19 African countries and isolated between 1979 and 2017, here we show a thorough scaled appraisal of the population structure of iNTS disease caused by S . Typhimurium across many of Africa’s most impacted countries. At least six invasive S . Typhimurium clades have already emerged, with ST313 lineage 2 or ST313-L2 driving the current pandemic. ST313-L2 likely emerged in the Democratic Republic of Congo around 1980 and further spread in the mid 1990s. We observed plasmid-borne as well as chromosomally encoded fluoroquinolone resistance underlying emergences of extensive-drug and pan-drug resistance. Our work provides an overview of the evolution of invasive S . Typhimurium disease, and can be exploited to target control measures. |
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Language
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English
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Source (journal)
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Nature communications
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Publication
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2023
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ISSN
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2041-1723
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DOI
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10.1038/S41467-023-41152-6
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Volume/pages
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14
:1
(2023)
, p. 1-17
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Article Reference
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6392
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ISI
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001100643800014
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Pubmed ID
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37872141
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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