Publication
Title
Small RNAs regulating biofilm formation and outer membrane homeostasis
Author
Abstract
Nowadays, the identification of small non-coding RNAs takes a prominent role in deciphering complex bacterial phenotypes. Evidences are given that the post-transcriptional layer of regulation mediated by sRNAs plays an important role in the formation of bacterial biofilms. These sRNAs exert their activity on various targets, be it directly or indirectly linked to biofilm formation. First, and best described, are the sRNAs that act in core regulatory pathways of biofilm formation, such as those regulating motility and matrix production. Second, overlaps between the regulation of biofilm formation and the outer membrane (OM) are becoming obvious. Additionally, different studies indicate that defects in the OM itself affect biofilm formation through this shared cascade, thereby forming a feedback mechanism. Interestingly, it is known that the OM itself is extensively regulated by different sRNAs. Third, biofilms are also linked to global metabolic changes. There is also evidence that metabolic pathways and the process of biofilm formation share sRNAs.
Language
English
Source (journal)
RNA biology
Publication
Austin : Landes bioscience , 2013
ISSN
1547-6286
1555-8584
DOI
10.4161/RNA.23341
Volume/pages
10 :2 (2013) , p. 185-191
ISI
000315591500004
Pubmed ID
23324602
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identifier
Creation 31.10.2023
Last edited 01.11.2023
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