Publication
Title
Is vestibular function related to human hippocampal volume?
Author
Abstract
BACKGROUND: Recent studies implicate the effect of vestibular loss on cognitive decline, including hippocampal volume loss. As hippocampal atrophy is an important biomarker of Alzheimer’s disease, exploring vestibular dysfunction as a risk factor for dementia and its role in hippocampal atrophy is of interest. OBJECTIVE: To replicate previous literature on whole-brain and hippocampal volume in semicircular canal dysfunction (bilateral vestibulopathy; BV) and explore the association between otolith function and hippocampal volume. METHODS: Hippocampal and whole-brain MRI volumes were compared in adults aged between 55 and 83 years. Participants with BV (n = 16) were compared to controls individually matched on age, sex, and hearing status (n = 16). Otolith influence on hippocampal volume in preserved semicircular canal function was evaluated (n = 34). RESULTS: Whole-brain and targeted hippocampal approaches using volumetric and surface-based measures yielded no significant differences when comparing BV to controls. Binary support vector machines were unable to classify inner ear health status above chance level. Otolith parameters were not associated with hippocampal volume in preserved semicircular canal function. CONCLUSIONS: No significant differences in whole-brain or hippocampal volume were found when comparing BV participants with healthy controls. Saccular parameters in subjects with preserved semicircular canal function were not associated with hippocampal volume changes.
Language
English
Source (journal)
Journal of vestibular research: an international journal of experimental and clinical vestibular science. - Amsterdam
Publication
Amsterdam : 2024
ISSN
0957-4271
0957-4271
DOI
10.3233/VES-230076
Volume/pages
34 :1 (2024) , p. 3-13
ISI
001193537600002
Pubmed ID
37927291
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
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Affiliation
Publications with a UAntwerp address
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Creation 07.11.2023
Last edited 03.05.2024
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