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Title
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Ocular surface homeostasis after scleral lens usage
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Author
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Abstract
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| Objectives:The aim of this prospective study is to examine the effects of 5 hours of well-fitted, mini-scleral contact lens (mini-SL) wear on the tear film cytokine expression in healthy eyes.Methods:Twenty-three healthy participants were included in the study. One eye of each participant was selected at random, and a mini-SL measuring 16.5 mm in diameter was fitted by an experienced contact lens specialist. The contact lens remained in place for 5 hours. Precorneal tear fluid was collected using capillary tubes at three different time points: baseline before SL insertion (T0), after 5 hours of SL wear (T1), and 3 hours after SL removal (T2). The concentration of 40 inflammatory cytokines at the three different time points was determined using multiplex bead assay.Results:Mini-scleral lens wear did not result in significant changes in the cytokine-to-protein ratio after 5 hours of wear on a healthy eye.Conclusions:Although a well-fitted mini-SL reduces the rate at which the precorneal tear film is refreshed, 5 hours of lens wear did not appear to significantly affect the tears cytokine-to-protein ratio, suggesting that scleral lenses have minimal impact on corneal cytokine expression. |
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Language
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English
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Source (journal)
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Eye & contact lens: science and clinical practice
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Publication
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2023
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ISSN
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1542-2321
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DOI
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10.1097/ICL.0000000000001027
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Volume/pages
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49
:11
(2023)
, p. 459-463
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ISI
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001091502600003
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Pubmed ID
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37651199
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Full text (Publisher's DOI)
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Full text (open access)
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