Title
|
|
|
|
Joint status, pain and quality of life in elderly people with haemophilia : a case-control study
| |
Author
|
|
|
|
| |
Abstract
|
|
|
|
Introduction: Elderly people with haemophilia (PwH) develop haemophilic arthropathy, pain, and reduced health-related quality of life (HR-QoL). The condition of elderly mild haemophilia patients have rarely been evaluated. This study aimed to compare joint status, pain, and HR-QoL between elderly with mild, moderate/severe haemophilia and healthy elderlies.Methods: Knee/ankle abnormalities were assessed by ultrasound (HEAD-US) and physical examination (HJHS 2.1). Pain severity and pain interference were investigated using the Brief Pain Inventory. Pressure pain thresholds (PPTs) were obtained at knees/ankles and forehead. Functional limitations were evaluated using the 2-Minute-Walking-Test, Timed-Up-and-Go and HAL. The EQ-5D-5L questionnaire evaluated HR-QoL. Healthy controls (HCs) and elderly individuals with moderate/severe and mild haemophilia were compared using Kruskal-Wallis and Mann-Whitney U tests.Results: From the 46 elderly PwH approached, 40 individuals (>= 60 years) with haemophilia A/B (17 moderate/severe; 23 mild) and 20 age-matched HCs were recruited. Moderate/severe PwH displayed worse joint status, lower PPTs, and poorer HR-QoL than mild PwH and HCs (p-value = .010-<.001). HEAD-US abnormalities were observed in 100% of knees and 94% of ankles in moderate/severe PwH, versus 50% of knees and 61% of ankles in mild PwH. Pain was reported by 80% and 57% of moderate/severe and mild PwH, respectively. Low PPTs, functional limitations, and poor HR-QoL scores were likewise observed in some mild PwH, yet without significantly differing from HCs.Conclusion: This study highlights poor joint/functional status, pain, and HR-QoL outcomes in elderly with moderate/severe haemophilia. A few mild haemophilia subjects presented joint abnormalities, pain, functional limitations, and poor HR-QoL, without significantly differing from HCs. |
| |
Language
|
|
|
|
English
| |
Source (journal)
|
|
|
|
Haemophilia / World Federation of Hemophilia. - Oxford
| |
Publication
|
|
|
|
Hoboken
:
Wiley
,
2023
| |
ISSN
|
|
|
|
1351-8216
| |
DOI
|
|
|
|
10.1111/HAE.14890
| |
Volume/pages
|
|
|
|
29
:6
(2023)
, p. 1621-1632
| |
ISI
|
|
|
|
001086052100001
| |
Pubmed ID
|
|
|
|
37861076
| |
Full text (Publisher's DOI)
|
|
|
|
| |
Full text (publisher's version - intranet only)
|
|
|
|
| |
|