Publication
Title
Novel therapeutic strategies in pancreatic cancer : moving beyond cytotoxic chemotherapy
Author
Abstract
Introduction: Prognosis of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) remains disappointing with a 5-year overall survival of only 3-5%. Compared to other cancers, the evolution in standard therapeutic options has been stagnant and polychemotherapy regimens (with well-known toxicity profile and resistance pattern) remain standard of care. Only for patients (5%-7%) with a breast cancer gene (BRCA) pathogenic germline variant, prognosis has improved by the use of olaparib (poly-ADP ribose polymerase (PARP) inhibitor).Areas covered: This review covers emerging treatment strategies in the management of mPDAC. One of the main topics is the rigid and immunological cold tumor microenvironment (TME) of PDAC and the search for agents that impact this TME and/or engage the immune system. In addition, the use of next-generation sequencing (NGS) has elicited for some patients new targeted therapies directed at alterations in the RTK/RAS/MAPK pathway and the deoxyribonucleic acid (DNA) damage repair pathway. Other evolving treatment strategies are also discussed.Expert opinion: The search for new, often combination, treatment strategies for mPDAC should be encouraged and implemented in early treatment lines given the significant decline of performance status of patients in later lines. NGS analysis should be used where available, although cost-effectiveness could be debatable.
Language
English
Source (journal)
Expert review of anticancer therapy. - London, 2001, currens
Publication
Abingdon : Taylor & francis ltd , 2023
ISSN
1473-7140 [print]
1744-8328 [online]
DOI
10.1080/14737140.2023.2270161
Volume/pages
23 :12 (2023) , p. 1237-1249
ISI
001085726000001
Pubmed ID
37842857
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Project info
Liquid biopsies for diagnosis, prognosis and follow-up of neuroendocrine neoplasms: clinical translation of novel technologies for (epi)genetic biomarker detectio.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 04.12.2023
Last edited 08.01.2024
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