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Title
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Impact of domiciliary administration of NSAIDs on COVID-19 hospital outcomes : an unCoVer analysis
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Author
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Abstract
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| Background: Effective domiciliary treatment can be useful in the early phase of COVID-19 to limit disease progression, and pressure on hospitals. There are discrepant data on the use of non-steroidal anti-inflammatory drugs (NSAIDs). Aim of this study is to evaluate whether the clinical outcome of patients who were hospitalized for COVID-19 is influenced by domiciliary treatment with NSAIDs. Secondary objective was to explore the association between other patient characteristics/therapies and outcome.Methods: A large dataset of COVID-19 patients was created in the context of a European Union-funded project (unCoVer). The primary outcome was explored using a study level random effects meta-analysis for binary (multivariate logistic regression models) outcomes adjusted for selected factors, including demographics and other comorbidities.Results: 218 out of 1,144 patients reported use of NSAIDs before admission. No association between NSAIDs use and clinical outcome was found (unadj. OR: 0.96, 95%CI: 0.68-1.38). The model showed an independent upward risk of death with increasing age (OR 1.06; 95% CI 1.05-1.07) and male sex (1.36; 95% CI 1.04-1.76).Conclusion: In our study, the domiciliary use of NSAIDs did not show association with clinical outcome in patients hospitalized with COVID-19. Older ages and male sex were associated to an increased risk of death. |
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Language
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English
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Source (journal)
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Frontiers in pharmacology. - [Lausanne, 2010, currens
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Publication
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[Lausanne
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Frontiers Media]
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2023
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ISSN
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1663-9812
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DOI
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10.3389/FPHAR.2023.1252800
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Volume/pages
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14
(2023)
, p. 1-5
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Article Reference
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1252800
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ISI
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001087430800001
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Pubmed ID
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37876733
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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