Publication
Title
Diagnostic significance of tryptase for suspected mast cell disorders
Author
Abstract
Tryptase has proven to be a very useful and specific marker to demonstrate mast cell activation and degranulation when an acute (i.e., within 4 h after the event) and baseline value (i.e., at least 24 h after the event) are compared and meet the consensus formula (i.e., an increase of 20% + 2). The upper limit of normal determined by the manufacturer is 11.4 ng/mL; however, this boundary has been the subject of debate. According to ECNM and AIM experts, the normal range of baseline tryptase should be 1 to 15 ng/mL. A genetic trait, hereditary alpha tryptasemia, characterized by an increased alpha coding TPSAB1 copy number is associated with a baseline value above 8 ng/mL. Elevated tryptase can also be found in chronic kidney disease, obesity, and hematological neoplasms. A tryptase > 20 ng/mL serves as a minor criterion to diagnose systemic mastocytosis and an increase in tryptase > 20% + 2 during an acute event is a required criterion in the diagnosis of mast cell activation syndrome. The goal of this review is to demonstrate the (in)significance of tryptase using some clinical vignettes and to provide a practical guide on how to manage and interpret an elevated tryptase level.
Language
English
Source (journal)
Diagnostics
Publication
2023
ISSN
2075-4418
DOI
10.3390/DIAGNOSTICS13243662
Volume/pages
13 :24 (2023) , p. 1-12
Article Reference
3662
ISI
001132619500001
Pubmed ID
38132246
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Role of inhibitory receptors in piecemeal and anaphylactic degranulation of basophils and mast cells.
Can behaviour analysis of individual mast cells and basophils lift the veil of anaphylaxis in mastocytosis?
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 18.12.2023
Last edited 16.02.2024
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