Publication
Title
The quest for circulating biomarkers in neuroendocrine neoplasms : a clinical perspective
Author
Abstract
Given the considerable heterogeneity in neuroendocrine neoplasms (NENs), it appears unlikely that a sole biomarker exists capable of fully capturing all useful clinical aspects of these tumors. This is reflected in the abundant number of biomarkers presently available for the diagnosis, prognosis, and monitoring of NEN patients. Although assessment of immunohistochemical and radiological markers remains paramount and often obligatory, there has been a notable surge of interest in circulating biomarkers over the years given the numerous benefits associated with liquid biopsies. Currently, the clinic primarily relies on single-analyte assays such as the chromogranin A assay, but these are far from ideal because of limitations such as compromised sensitivity and specificity as well as a lack of standardization. Consequently, the quest for NEN biomarkers continued with the exploration of multianalyte markers, exemplified by the development of the NETest and ctDNA-based analysis. Here, an extensive panel of markers is simultaneously evaluated to identify distinct signatures that could enhance the accuracy of patient diagnosis, prognosis determination, and response to therapy prediction and monitoring. Given the promising results, the development and implementation of these multianalyte markers are expected to usher in a new era of NEN biomarkers in the clinic. In this review, we will outline both clinically implemented and more experimental circulating markers to provide an update on developments in this rapidly evolving field.
Language
English
Source (journal)
Current treatment options in oncology. - Philadelphia, Pa, 2000, currens
Publication
Philadelphia, Pa : Current Science , 2023
ISSN
1527-2729 [print]
1534-6277 [online]
DOI
10.1007/S11864-023-01147-3
Volume/pages
24 :12 (2023) , p. 1833-1851
ISI
001103996500001
Pubmed ID
37989978
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Improving diagnostic accuracy and follow-up of neuroendocrine neoplasms through detection of (epi)genetic biomarkers in liquid biopsies using novel technological platforms.
Liquid biopsies for diagnosis, prognosis and follow-up of neuroendocrine neoplasms: clinical translation of novel technologies for (epi)genetic biomarker detectio.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 18.12.2023
Last edited 23.05.2024
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