Publication
Title
Straightforward synthesis of functionalized γ-Lactams using impure CO₂ stream as the carbon source
Author
Abstract
Direct utilization of CO2 into organic synthesis finds enormous applications to synthesize pharmaceuticals and fine chemicals. However, pure CO2 gas is essential to achieve these transformations, and the purification of CO2 is highly cost and energy intensive. Considering this, we describe a straightforward synthetic route for the synthesis of gamma-lactams, a pivotal core structure of bioactive molecules, by using commercially available starting materials (alkenes and amines) and impure CO2 stream (exhaust gas is collected from the car) as the carbon source. This blueprint features a broad scope, excellent functional group compatibility and application to the late-stage transformation of existing pharmaceuticals and natural products to synthesize functionalized gamma-lactams. We believe that our strategy will provide direct access to gamma-lactams in a very sustainable way and will also enhance the Carbon Capture and Utilization (CCU) strategy.
Language
English
Source (journal)
Nature communications
Publication
2023
ISSN
2041-1723
DOI
10.1038/S41467-023-43289-W
Volume/pages
14 :1 (2023) , p. 1-9
Article Reference
7604
ISI
001109292400003
Pubmed ID
37989749
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 09.01.2024
Last edited 11.01.2024
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