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Title
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Design and analysis of a microplate assay in the presence of multiple restrictions on the randomization
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Author
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Abstract
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| Experiments using multi-step protocols often involve several restrictions on the randomization. For a specific application to in vitro testing on microplates, a design was required with both a split-plot and a strip-plot structure. On top of two-level treatment factors and the factors that define the randomization restrictions, a multi-level fixed blocking factor not involving further restrictions on the randomization had to be added. We develop a step-by-step approach to construct a design for the microplate experiment and analyze a response. To consolidate the approach, we study various alternative scenarios for the experiment.Supplementary materials accompanying this paper appear online |
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Language
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English
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Source (journal)
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Journal of agricultural, biological, and environmental statistics / American Statistical Association; International Biometric Society. - Alexandria, Va, 1996, currens
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Publication
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New york
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Springer
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2023
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ISSN
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1085-7117
[print]
1537-2693
[online]
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DOI
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10.1007/S13253-023-00570-1
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Volume/pages
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(2023)
, p. 1-21
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ISI
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001118748200001
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Full text (Publisher's DOI)
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Full text (open access)
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The author-created version that incorporates referee comments and is the accepted for publication version Available from 16.10.2024
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Full text (publisher's version - intranet only)
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