Publication
Title
Injectable plasma-treated alginate hydrogel for oxidative stress delivery to induce immunogenic cell death in osteosarcoma
Author
Abstract
Cold atmospheric plasma (CAP) is a source of cell-damaging oxidant molecules that may be used as low-cost cancer treatment with minimal side effects. Liquids treated with cold plasma and enriched with oxidants are a modality for non-invasive treatment of internal tumors with cold plasma via injection. However, liquids are easily diluted with body fluids which impedes high and localized delivery of oxidants to the target. As an alternative, plasma-treated hydrogels (PTH) emerge as vehicles for the precise delivery of oxidants. This study reports an optimal protocol for the preparation of injectable alginate PTH that ensures the preservation of plasma-generated oxidants. The generation, storage, and release of oxidants from the PTH are assessed. The efficacy of the alginate PTH in cancer treatment is demonstrated in the context of cancer cell cytotoxicity and immunogenicity-release of danger signals and phagocytosis by immature dendritic cells, up to now unexplored for PTH. These are shown in osteosarcoma, a hard-to-treat cancer. The study aims to consolidate PTH as a novel cold plasma treatment modality for non-invasive or postoperative tumor treatment. The results offer a rationale for further exploration of alginate-based PTHs as a versatile platform in biomedical engineering. A plasma-treated hydrogels (PTH) is proposed as a vehicle for the delivery of reactive oxygen and nitrogen species to internal tumors. Here, an injectable and shape-adaptable alginate PTH is reported for minimally invasive or post-operative cancer treatment. The PTH can release plasma-derived oxidants to kill osteosarcoma cells and induce the release of danger signals to promote their phagocytic uptake by immune cells.image
Language
English
Source (journal)
Advanced functional materials. - Weinheim
Publication
Weinheim : Wiley-v c h verlag gmbh , 2023
ISSN
1616-301X
DOI
10.1002/ADFM.202312005
Volume/pages
(2023) , p. 1-13
ISI
001129424500001
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Investigation of non-thermal plasma therapy with first-line treatments of recurrent and metastatic head and neck squamous cell carcinoma: a novel combination with platinum-based chemotherapy and immunotherapy.
From physical plasma to cellular pathway: a multi-disciplinary approach to unravel the response pathways induced by nonthermal plasma for cancer therapy.
Investigating fundamental plasma effects on tumor microenvironment through development of a controlled plasma treatment system for clinical cancer therapy.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 09.01.2024
Last edited 11.01.2024
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