Publication
Title
Insulin resistance and CGM-derived parameters in people with type 1 diabetes : are they associated?
Author
Abstract
Background: Insulin resistance (IR) is increasingly more prevalent in people with type 1 diabetes (T1D). We investigated whether IR is associated with continuous glucose monitor (CGM)-derived parameters (glucometrics) such as time in range (TIR), time above range (TAR), time below range (TBR) and glycaemic variability (CV). Methods: This is a retrospective analysis of two databases: IR was quantified according to the estimated glucose disposal rate (eGDR) (NCT04664036) and by performing a hyperinsulinaemic-euglycaemic clamp (HEC) (NCT04623320). All glucometrics were calculated over 28 days. Results: A total of 287 subjects were included. Mean age was 46 ± 17 years, 55% were male, TIR was 57 ± 14% and eGDR was 7.6 (5.6 - 9.3) mg/kg min. The tertile of people with the lowest eGDR (highest level of IR) had a higher TAR compared to the tertile with the highest eGDR (39 ± 15% versus 33 ± 14, p = 0.043). Using logistic regression, a higher eGDR was associated with a higher chance to fall in a higher TIR- (OR 1.251, p < 0.001), a lower TAR- (OR 1.281, p < 0.001) and a higher TBR-tertile (OR 0.893, p = 0.039), adjusted for age, sex, diabetes duration, smoking status and alcohol intake. In the 48 people undergoing a HEC, no significant association between glucometrics and the HEC-determined glucose disposal rate (M-value) was observed. Conclusion: In people with T1D, an association between IR, measured by eGDR, and worse CGM profiles was observed.
Language
English
Source (journal)
The journal of clinical endocrinology and metabolism. - Baltimore, Md
Publication
Baltimore, Md : 2024
ISSN
0021-972X
DOI
10.1210/CLINEM/DGAE015
Volume/pages
(2024) , 36 p.
Article Reference
dgae015
Pubmed ID
38198792
Full text (Publisher's DOI)
Full text (open access)
The author-created version that incorporates referee comments and is the accepted for publication version Available from 10.07.2024
UAntwerpen
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Publications with a UAntwerp address
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Creation 18.01.2024
Last edited 23.01.2024
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