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Title
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Insulin resistance and CGM-derived parameters in people with type 1 diabetes : are they associated?
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Author
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Abstract
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| Background: Insulin resistance (IR) is increasingly more prevalent in people with type 1 diabetes (T1D). We investigated whether IR is associated with continuous glucose monitor (CGM)-derived parameters (glucometrics) such as time in range (TIR), time above range (TAR), time below range (TBR) and glycaemic variability (CV). Methods: This is a retrospective analysis of two databases: IR was quantified according to the estimated glucose disposal rate (eGDR) (NCT04664036) and by performing a hyperinsulinaemic-euglycaemic clamp (HEC) (NCT04623320). All glucometrics were calculated over 28 days. Results: A total of 287 subjects were included. Mean age was 46 ± 17 years, 55% were male, TIR was 57 ± 14% and eGDR was 7.6 (5.6 - 9.3) mg/kg min. The tertile of people with the lowest eGDR (highest level of IR) had a higher TAR compared to the tertile with the highest eGDR (39 ± 15% versus 33 ± 14, p = 0.043). Using logistic regression, a higher eGDR was associated with a higher chance to fall in a higher TIR- (OR 1.251, p < 0.001), a lower TAR- (OR 1.281, p < 0.001) and a higher TBR-tertile (OR 0.893, p = 0.039), adjusted for age, sex, diabetes duration, smoking status and alcohol intake. In the 48 people undergoing a HEC, no significant association between glucometrics and the HEC-determined glucose disposal rate (M-value) was observed. Conclusion: In people with T1D, an association between IR, measured by eGDR, and worse CGM profiles was observed. |
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Language
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English
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Source (journal)
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The journal of clinical endocrinology and metabolism. - Baltimore, Md
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Publication
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Baltimore, Md
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2024
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ISSN
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0021-972X
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DOI
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10.1210/CLINEM/DGAE015
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Volume/pages
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109
:11
(2024)
, p. e2131-e2140
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ISI
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001149644500001
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Pubmed ID
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38198792
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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