Publication
Title
Resting-state functional MRI and PET imaging as noninvasive tools to study (ab)normal neurodevelopment in humans and rodents
Author
Abstract
Neurodevelopmental disorders (NDDs) are a group of complex neurologic and psychiatric disorders. Functional and molecular imaging techniques, such as resting-state functional magnetic resonance imaging (rs-fMRI) and positron emission tomography (PET), can be used to measure network activity noninvasively and longitudinally during maturation in both humans and rodent models. Here, we review the current knowledge on rs-fMRI and PET biomarkers in the study of normal and abnormal neurodevelopment, including intellectual disability (ID; with/without epilepsy), autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD), in humans and rodent models from birth until adulthood, and evaluate the cross-species translational value of the imaging biomarkers. To date, only a few isolated studies have used rs-fMRI or PET to study (abnormal) neurodevelopment in rodents during infancy, the critical period of neurodevelopment. Further work to explore the feasibility of performing functional imaging studies in infant rodent models is essential, as rs-fMRI and PET imaging in transgenic rodent models of NDDs are powerful techniques for studying disease pathogenesis, developing noninvasive preclinical imaging biomarkers of neurodevelopmental dysfunction, and evaluating treatment-response in disease-specific models.
Language
English
Source (journal)
The journal of neuroscience. - Baltimore, Md
Publication
Baltimore, Md : 2023
ISSN
0270-6474 [Print]
1529-2401 [Online]
DOI
10.1523/JNEUROSCI.1043-23.2023
Volume/pages
43 :49 (2023) , p. 8275-8293
ISI
001173261800002
Pubmed ID
38073598
Full text (Publisher's DOI)
Full text (open access)
The author-created version that incorporates referee comments and is the accepted for publication version Available from 06.06.2024
UAntwerpen
Faculty/Department
Research group
Project info
The hidden genetics of Developmental and Epileptic Encephalopathies: a multi-omics approach.
Allele-specific silencing of mutant KCNQ2 as a targeted treatment for KCNQ2 encephalopathy: an in vitro proof of concept study.
Mutant allele silencing and novel potassium channel openers as targeted treatment strategies for KCNQ2 encephalopathy: validation in induced pluripotent stem cell derived neuronal cultures.
A multi-omics approach to the detection of pathologic genetic and epigenetic lesions in Developmental and Epileptic Encephalopathies
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Record
Identifier
Creation 12.02.2024
Last edited 02.04.2024
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