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Title
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The role of Helicobacter suis, Fusobacterium gastrosuis, and the pars oesophageal microbiota in gastric ulceration in slaughter pigs receiving meal or pelleted feed
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Author
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Abstract
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| This study investigated the role of causative infectious agents in ulceration of the non-glandular part of the porcine stomach ( pars oesophagea ). In total, 150 stomachs from slaughter pigs were included, 75 from pigs that received a meal feed, 75 from pigs that received an equivalent pelleted feed with a smaller particle size. The pars oesophagea was macroscopically examined after slaughter. (q)PCR assays for H. suis , F. gastrosuis and H. pylori -like organisms were performed, as well as 16S rRNA sequencing for pars oesophagea microbiome analyses. All 150 pig stomachs showed lesions. F. gastrosuis was detected in 115 cases (77%) and H. suis in 117 cases (78%), with 92 cases (61%) of co-infection; H. pylori -like organisms were detected in one case. Higher infectious loads of H. suis increased the odds of severe gastric lesions (OR = 1.14, p = 0.038), while the presence of H. suis infection in the pyloric gland zone increased the probability of pars oesophageal erosions [16.4% (95% CI 0.6–32.2%)]. The causal effect of H. suis was mediated by decreased pars oesophageal microbiome diversity [−1.9% (95% CI − 5.0–1.2%)], increased abundances of Veillonella and Campylobacter spp., and decreased abundances of Lactobacillus , Escherichia-Shigella , and Enterobacteriaceae spp. Higher infectious loads of F. gastrosuis in the pars oesophagea decreased the odds of severe gastric lesions (OR = 0.8, p = 0.0014). Feed pelleting had no significant impact on the prevalence of severe gastric lesions (OR = 1.72, p = 0.28). H. suis infections are a risk factor for ulceration of the porcine pars oesophagea , probably mediated through alterations in pars oesophageal microbiome diversity and composition. |
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Language
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English
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Source (journal)
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Veterinary research. - Paris
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Publication
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Paris
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2024
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ISSN
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0928-4249
1297-9716
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DOI
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10.1186/S13567-024-01274-1
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Volume/pages
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55
:1
(2024)
, p. 1-15
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Article Reference
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15
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ISI
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001158154400003
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Pubmed ID
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38317242
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Full text (Publisher's DOI)
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Full text (open access)
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