Publication
Title
Exploring anatomical brain heterogeneity in subjects with mild cognitive impairment
Author
Institution/Organisation
Alzheimer's Dis Neuroimaging Initiative
Abstract
The wide range of clinical manifestations in Mild Cognitive Impairment (MCI) poses a significant challenge. The inherent heterogeneity within MCI emphasizes the importance of a comprehensive characterization of individuals diagnosed with this condition. We identified and characterized MCI subgroups with distinct neuropsychological profiles within the Alzheimer's Disease Neuroimaging Initiative. A total of 194 individuals diagnosed with MCI were partitioned into 7 subgroups using a data-driven clustering approach that incorporated followup information. Voxel-based morphometry was then utilized to investigate patterns of gray matter atrophy in each of these subgroups, comparing them against 108 cognitively normal individuals. The analysis disclosed specific brain regions with significant differences. A remarkable relationship between cognitive impairment and the extent of brain atrophy was observed. Increasing cognitive and behavioral abnormalities corresponded to more extensive gray matter atrophy patterns. This study enhances the understanding of neurodegenerative patterns in mild cognitive impairment, providing valuable perspectives for improved characterization and potential interventions in the prodromal stage of Alzheimer's Disease.
Language
English
Source (book)
19th International Symposium on Medical Information Processing and, Analysis (SIPAIM), NOV 15-17, 2023, Mexico City, Mexico
Publication
New york : Ieee , 2023
ISBN
979-83-503-2523-2
DOI
10.1109/SIPAIM56729.2023.10373453
Volume/pages
(2023) , p. 1-5
ISI
001156693600020
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 04.03.2024
Last edited 14.03.2024
To cite this reference