Publication
Title
Diagnostic performance of cerebrospinal fluid neurofilament light chain and soluble amyloid-β protein precursor β in the subcortical small vessel type of dementia
Author
Abstract
Background: The subcortical small vessel type of dementia (SSVD) is a common subtype of vascular dementia, but there is a lack of disease-specific cerebrospinal fluid (CSF) biomarkers. Objective: We investigated whether CSF concentrations of neurofilament light chain (NFL), soluble amyloid-beta protein precursor alpha (sA beta PP alpha), sA beta PP beta, and CSF/serum albumin ratio could separate SSVD from healthy controls, Alzheimer's disease (AD), and mixed dementia (combined AD and SSVD). Methods: This was a mono-center study of patients with SSVD (n = 38), AD (n = 121), mixed dementia (n = 62), and controls (n = 96). The CSF biomarkers were measured using immunoassays, and their independent contribution to the separation between groups were evaluated using theWald test. Then, the area under the receiver operating characteristics curve (AUROC) and 95% confidence intervals (CIs) were calculated. Results: Elevated neurofilament light chain (NFL) and decreased sA beta PP beta independently separated SSVD from controls, and sA beta PP beta also distinguished SSVD from AD and mixed dementia. The combination of NFL and sA beta PP beta discriminated SSVD from controls with high accuracy (AUROC 0.903, 95% CI: 0.834-0.972). Additionally, sA beta PP beta combined with the core AD biomarkers (amyloid-(beta 42), total tau, and phosphorylated tau181) had a high ability to separate SSVD from AD (AUROC 0.886, 95% CI: 0.830-0.942) and mixed dementia (AUROC 0.903, 95% CI: 0.838-0.968). Conclusions: The high accuracy of NFL and sA beta PP beta to separate SSVD from controls supports that SSVD is a specific diagnostic entity. Moreover, SSVD was distinguished from AD and mixed dementia using sA beta PP beta in combination with the core AD biomarkers.
Language
English
Source (journal)
Journal of Alzheimer's disease. - -
Publication
2023
ISSN
1387-2877
1875-8908 [Electronic]
DOI
10.3233/JAD-230680
Volume/pages
96 :4 (2023) , p. 1515-1528
ISI
001136443600012
Pubmed ID
37980667
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 04.03.2024
Last edited 08.03.2024
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