Publication
Title
Positioning the preventive potential of microbiome treatments for cystic fibrosis in the context of current therapies
Author
Abstract
Antibiotics and cystic fibrosis transmembrane conductance regulator (CFTR) modulators play a pivotal role in cystic fibrosis (CF) treatment, but both have limitations. Antibiotics are linked to antibiotic resistance and disruption of the airway microbiome, while CFTR modulators are not widely accessible, and structural lung damage and pathogen overgrowth still occur. Complementary strategies that can beneficially modulate the airway microbiome in a preventive way are highly needed. This could be mediated via oral probiotics, which have shown some improvement of lung function and reduction of airway infections and exacerbations, as a cost-effective approach. However, recent data suggest that specific and locally administered probiotics in the respiratory tract might be a more targeted approach to prevent pathogen outgrowth in the lower airways. This review aims to summarize the current knowledge on the CF airway microbiome and possibilities of microbiome treatments to prevent bacterial and/or viral infections and position them in the context of current CF therapies.
Language
English
Source (journal)
Cell reports medicine
Publication
2024
DOI
10.1016/J.XCRM.2023.101371
Volume/pages
5 :1 (2024) , p. 1-14
Article Reference
101371
ISI
001167816800001
Pubmed ID
38232705
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Insights into the lifestyle and adaptation factors of Dolosigranlum pigrum as probiotic for the upper respiratory tract.
Unraveling direct interactions between the airway microbiota and respiratory syncytial virus.
Bead-enabled capturing and fluorescent labeling to quantify direct respiratory virus-microbiota interactions.
Insights into viral and bacterial colonisation of the lower respiratory tract in cystic fibrosis patients through metagenomic sequencing and multiplex qPCR.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Record
Identifier
Creation 05.03.2024
Last edited 03.04.2024
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