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Title
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Very rare tumour of the palatine tonsil : a molecular approach
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Author
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Abstract
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| Mucoepidermoid cancer (MEC) is extremely rare in the palatine tonsil with only three adequately described cases in the literature.We describe a woman in her late 70s with vague pharyngeal discomfort who underwent tonsillectomy, lymph node dissection of the neck and radiotherapy for MEC with loco-regional lymph node metastasis of the palatine tonsil. To confirm this extremely rare diagnosis and to gain deeper insight in the molecular oncogenesis, an extensive molecular study including next-generation sequencing and immunohistochemistry was performed. Immunoreactivity for p16 protein and real-time PCR showed high-risk oncogenic human papillomavirus 16 DNA and mutations in the BRAF, BARD and DNMT3A genes. Tumour mutational burden was low. After a follow-up of 7 years the patient is still alive and well without any residual or disseminated disease. |
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Language
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English
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Source (journal)
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BMJ case reports. - London, 2008, currens
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Publication
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London
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BMJ Pub. Group
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2024
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ISSN
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1757-790X
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DOI
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10.1136/BCR-2023-255864
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Volume/pages
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17
:1
(2024)
, p. 1-7
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Article Reference
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e255864
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ISI
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001143666200067
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Pubmed ID
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38216164
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Full text (Publisher's DOI)
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