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Title
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Pathophysiology and clinical relevance of atrial myopathy
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Author
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Abstract
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| Atrial myopathy is a condition that consists of electrical, structural, contractile, and autonomic remodeling of the atria and is the substrate for development of atrial fibrillation, the most common arrhythmia. Pathophysiologic mechanisms driving atrial myopathy are inflammation, oxidative stress, atrial stretch, and neurohormonal signals, e.g., angiotensin-II and aldosterone. These mechanisms initiate the structural and functional remodeling of the atrial myocardium. Novel therapeutic strategies are being developed that target the pathophysiologic mechanisms of atrial myopathy. In this review, we will discuss the pathophysiology of atrial myopathy, as well as diagnostic and therapeutic strategies. |
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Language
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English
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Source (journal)
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Basic research in cardiology / German Cardiac Society. - Heidelberg, 1973, currens
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Publication
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Heidelberg
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Springer heidelberg
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2024
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ISSN
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0300-8428
[print]
1435-1803
[online]
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DOI
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10.1007/S00395-024-01038-0
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Volume/pages
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119
:2
(2024)
, p. 215-242
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ISI
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001181124800001
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Pubmed ID
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38472506
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Full text (Publisher's DOI)
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Full text (open access)
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The author-created version that incorporates referee comments and is the accepted for publication version Available from 12.09.2024
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Full text (publisher's version - intranet only)
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