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Title
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Evaluation of glucose metrics in adults with type 1 diabetes switching to insulin glargine 300 U/mL : a retrospective, propensity-score matched study
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Author
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Abstract
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| Objectives: To study real-world effect of switching to Insulin Glargine 300 U/mL (Gla-300) on glucose metrics in people with type 1 diabetes. Methods: This retrospective secondary-use study compared 151 adults who switched to Gla-300 from first-generation long-acting insulins (Switchers) to 281 propensity-score matched controls (Non-switchers) who continued first-generation long-acting insulins. Primary endpoint was difference in time in range (TIR) evolution. A fictive "switching" date was assigned to Non-switchers to facilitate between-group comparisons. Results: In the period before switching, TIR decreased numerically for people in whom Gla-300 was eventually initiated (-0.05%/month [-0.16 to 0.07]), while it increased for matched controls (0.08%/month [0.02 to 0.015]; between-group difference P = 0.047). After Gla-300-initiation, Switchers had similar TIR increase compared to Non-switchers (P = 0.531). Switchers used higher basal dose than before switch (Delta 0.012 U/[kg center dot d] [0.006 to 0.018]; P < 0.0001). Conclusion: In real-life, Gla-300 was typically initiated in people where TIR was decreasing, which was reversed after switch using slightly higher basal insulin dose. |
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Language
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English
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Source (journal)
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Diabetes technology and therapeutics. - -
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Publication
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New rochelle
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Mary ann liebert, inc
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2024
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ISSN
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1557-8593
[online]
1520-9156
[print]
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DOI
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10.1089/DIA.2023.0371
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Volume/pages
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26
:7
(2024)
, p. 488-493
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ISI
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001180922400001
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Pubmed ID
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38386438
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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