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Title
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Evaluating an ebola vaccine regimen and booster dose among healthcare personnel of the Democratic Republic of the Congo : a step towards outbreak prevention
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Author
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Abstract
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| This doctoral thesis is focussed on the results of a phase 2, open-label, monocentric, randomised Ebola vaccine trial conducted in Boende, a remote and resource-constrained setting in the Democratic Republic of the Congo. Within the trial, 699 healthcare providers and frontliners were enrolled to receive the two-dose heterologous Ad26.ZEBOV, MVA-BN-Filo vaccine regimen followed by an Ad26.ZEBOV booster dose either one or two years after the first dose, depending on the randomisation group (ratio 1:1). After placing the trial within the context of existing literature, the doctoral thesis proceeds to detail the trial results and address the challenges, mitigations, and lessons learned from conducting the vaccine trial in a remote and resource-constrained area. Following this, it outlines recommended next steps in the fight against Ebola, emphasizing the importance of continued research, including long-term follow-up studies of previously vaccinated individuals. These follow-up studies should aim to contribute to a more comprehensive understanding of the Ad26.ZEBOV, MVA-BN-Filo vaccine regimen and booster dose, and their role in Ebola preparedness. Finally, the thesis concludes by advocating for proactive vaccination strategies for at-risk populations, particularly healthcare providers and frontliners living and working in Ebola-endemic regions, to minimize the impact of future Ebola outbreaks. |
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Language
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English
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Publication
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Antwerp
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University of Antwerp, Faculty of Medicine and Health Sciences
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2024
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DOI
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10.63028/10067/2052650151162165141
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Volume/pages
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318 p.
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Note
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Van Damme, Pierre [Supervisor]
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Van geertruyden, Jean-Pierre [Supervisor]
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Muhindo-Mavoko, Hypolite [Supervisor]
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Full text (open access)
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