Publication
Title
Therapeutic exploitation of ferroptosis
Author
Abstract
Pathological breakdown of membrane lipids through excessive lipid peroxidation (LPO) was first described in the mid-20th century and is now recognized as a form of regulated cell death, dubbed ferroptosis. Accumulating evidence unveils how metabolic regulation restrains peroxidation of phospholipids within cellular membranes, thereby impeding ferroptosis execution. Unleashing these metabolic breaks is currently therapeutically explored to sensitize cancers to ferroptosis inducing anti-cancer therapies. Reversely, these natural ferroptotic defense mechanisms can fail resulting in pathological conditions or diseases such as ischemia-reperfusion injury, multi-organ dysfunction, stroke, infarction, or neurodegenerative diseases. This minireview outlines current ferroptosis-inducing anti-cancer strategies and highlights the detection as well as the therapeutic targeting of ferroptosis in preclinical experimental settings. Herein, we also briefly summarize observations related to LPO, iron and redox deregulation in patients that might hint towards ferroptosis as a contributing factor.
Language
English
Source (journal)
Biochemical Society transactions. - London, 1973, currens
Publication
London : Biochemical Society , 2024
ISSN
0300-5127 [print]
1470-8752 [online]
DOI
10.1042/BST20230550
Volume/pages
(2024) , 14 p.
ISI
001206328600001
Pubmed ID
38629629
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Research group
Project info
Blocking ischemia reperfusion injury during dynamic preservation of organ grafts using lead ferroptosis inhibitors.
Blocking ischemia reperfusion injury during dynamic preservation of organ grafts using lead ferroptosis inhibitors.
Blocking ischemia reperfusion injury during dynamic preservation of organ grafts using lead ferroptosis inhibitors.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 02.05.2024
Last edited 15.05.2024
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