Publication
Title
Mitral valve surgery for mitral regurgitation results in reduced left ventricular ejection fraction in Barlow's disease as compared with fibro-elastic deficiency
Author
Abstract
Surgical correction of severe mitral regurgitation (MR) can reverse left ventricular (LV) remodeling in patients with mitral valve prolapse (MVP). However, whether this process is similar to the case in Barlow's Disease (BD) and Fibro-elastic Deficiency (FED) is currently unknown. The aim of this study is to evaluate post-operative LV reverse remodeling and function in patients with BD versus FED. In this study, 100 MVP patients (BD = 37 and FED = 63) with severe MR who underwent mitral valve surgery at three Belgian centers were retrospectively included. Transthoracic echocardiography was used to assess MR severity, LV volumes and function before surgery and 6 months thereafter. Baseline MR severity, LV ejection fraction (LVEF), indexed LV end-diastolic (LVEDVi) and end-systolic volumes (LVESVi) were not different between the groups. After a median follow-up of 278 days, there was a similar decrease in LVEDVi, but a trend towards a smaller decrease in LVESVi in BD compared to FED (-3.0 +/- 11.2 mL/m(2) vs. -5.3 +/- 9.0 mL/m(2); p = 0.154). This resulted in a significantly larger decrease in LVEF in BD (-8.3 +/- 9.6%) versus FED (-3.9 +/- 6.9%) after adjusting for baseline LVEF (p < 0.001) and type of surgical intervention (p = 0.01). These findings suggest that LV (reverse) remodeling in BD could be affected by other mechanisms beyond volume overload, potentially involving concomitant cardiomyopathy.
Language
English
Source (journal)
Journal of Cardiovascular Development and Disease. - Basel, Switzerland, 2015, currens
Publication
Basel, Switzerland : MDPI AG , 2024
ISSN
2308-3425
DOI
10.3390/JCDD11030071
Volume/pages
11 :3 (2024) , p. 1-11
Article Reference
71
ISI
001193520100001
Pubmed ID
38535094
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 02.05.2024
Last edited 08.05.2024
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