Publication
Title
Challenges and recent advancements in the synthesis of α,α-disubstituted α-amino acids
Author
Abstract
alpha,alpha-Disubstituted alpha-amino acids (alpha-AAs) have improved properties compared to other types of amino acids. They serve as modifiers of peptide conformation and as precursors of bioactive compounds. Therefore, it has been a long-standing goal to construct this highly valuable scaffold efficiently in organic synthesis and drug discovery. However, access to alpha,alpha-disubstituted alpha-AAs is highly challenging and largely unexplored due to their steric constraints. To overcome these, remarkable advances have been made in the last decades. Emerging strategies such as synergistic enantioselective catalysis, visible-light-mediated photocatalysis, metal-free methodologies and CO2 fixation offer new avenues to access the challenging synthesis of alpha,alpha-disubstituted alpha-AAs and continuously bring additional contributions to this field. This review article aims to provide an overview of the recent advancements since 2015 and discuss existing challenges for the synthesis of alpha,alpha-disubstituted alpha-AAs and their derivatives. alpha,alpha-Disubstituted alpha-amino acids (alpha-AAs) have improved properties compared to other amino acids. Here, the authors provide an overview of the recent advancements since 2015 and discuss existing challenges for their synthesis.
Language
English
Source (journal)
Nature communications
Publication
Berlin : Nature portfolio , 2024
ISSN
2041-1723
DOI
10.1038/S41467-024-45790-2
Volume/pages
15 :1 (2024) , p. 1-18
Article Reference
1474
ISI
001163800700018
Pubmed ID
38368416
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 02.05.2024
Last edited 09.05.2024
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