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Title
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The temporal relationship between body composition and cardiometabolic profiles in an HIV-infected (on antiretroviral therapy) versus HIV-free Western Cape study population
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Author
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Abstract
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| Cardiovascular risk is a health concern in people living with HIV/AIDS (PLWH). This longitudinal study (baseline vs 36 months) aimed to investigate the relationship between body composition and markers of cardiovascular risk in a South African study population [HIV free, n = 22 vs HIV positive on antiretroviral therapy (HIV+ART), n = 73)]. Health questionnaires, anthropometric measurements, biochemical analyses and flow -mediated dilation were performed. Linear mixedmodel statistical analyses were applied. The HIV+ART vs the HIV -free groups were independently associated with body mass index (BMI) [-4.92 (-7.99 to -1.84), p = 0.002] and waist circumference [-10.5 (-17.2 to -3.77), p = 0.003]. ART duration was associated with BMI [2.60 (0.57-4.62), p = 0.013], waist circumference [3.83 (0.03-7.63), p = 0.048] and highdensity lipoprotein cholesterol [20.18 (2.37-41.09), p = 0.025]. The data showed that intricate relationships existed in this study population between HIV, ART, body composition and cardiometabolic variables. There is a need for more research investigating cardiovascular risk in PLWH, particularly in the context of changes in body composition measures. |
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Language
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English
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Source (journal)
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Cardiovascular journal of Africa. - Durbanville
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Publication
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Durbanville
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Clinics cardive publ pty ltd
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2024
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ISSN
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1995-1892
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DOI
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10.5830/CVJA-2024-005
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Volume/pages
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(2024)
, p. 1-9
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ISI
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001198371900001
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Full text (Publisher's DOI)
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Full text (open access)
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