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Title
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Behavioral effects of vigabatrin correlated with whole brain -aminobutyric acid metabolism in audiogenic sensitive rats
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Author
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Abstract
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| The present study evaluates dose-dependent behavioral effects of acutely or subacutely administered single doses of vigabatrin (gamma-vinyl gamma-aminobutyric acid, gamma-vinyl GABA, CAS 60643-869) in audiogenic sensitive rats, in correlation with whole brain GABA metabolism. There was a discrepancy in timing between behaviorally observed maximal antiepileptic protection (4 h after i.p. administration of gamma-vinyl GABA) and on the other hand maximal inhibition of GABA-transaminase activity and maximal increase of whole brain GABA content (24 h after i.p, administration of gamma-vinyl GABA). This suggests that the antiepileptic properties of gamma-vinyl GABA not only depend on GABA-ergic neurotransmission. A possible explanation is a gamma-vinyl GABA-induced decrease of excitatory amino acids or increased glycine concentrations in the brain. |
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Language
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English
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Source (journal)
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Arzneimittelforschung. - Aulendorf
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Publication
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Aulendorf
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1998
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ISSN
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0004-4172
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Volume/pages
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48
:7
(1998)
, p. 713-715
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ISI
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000075125100001
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