Title
Determination of selected POPs in human serum by solid-phase disk extraction and dual-column capillary gas chromatography with electron capture detection Determination of selected POPs in human serum by solid-phase disk extraction and dual-column capillary gas chromatography with electron capture detection
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
New York, N.Y. ,
Subject
Chemistry
Biology
Source (journal)
International journal of environmental analytical chemistry. - New York, N.Y.
Volume/pages
76(2000) :3 , p. 167-178
ISSN
0306-7319
0306-7319
ISI
000088132300002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
An improved clean-up method by solid-phase disk extraction was developed to isolate and concentrate trace levels of POPs (persistent organochlorine pollutants) in human serum prior to gas chromatography with electron capture detection on two different capillary columns, providing an improved selectivity. An Empore(TM) C-18 bonded silica extraction disk cartridge is used for the initial extraction and enrichment of the analytes. Subsequent clean-up is achieved by concentrated sulphuric acid and silica gel adsorption chromatography, Recoveries for selected POPs are ranging from 62 to 74% and a good reproducibility (RSD < 14%) is demonstrated. Human samples analysed under these conditions, show a similar relative concentration profile.
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