Title
Vitamin A abuse : development of cirrhosis despite cessation of vitamin A : a six year clinical and histologic follow-up Vitamin A abuse : development of cirrhosis despite cessation of vitamin A : a six year clinical and histologic follow-up
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Human medicine
Source (journal)
Liver
Volume/pages
12(1992) :6 , p. 381-386
ISSN
0106-9543
ISI
A1992KF87300004
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
We report the case of a 35-year-old man who contracted vitamin A-induced liver cirrhosis. Five years before, he had been investigated for vitamin A-induced non-cirrhotic portal hypertension. In this case, the clinical and histopathologic evolution from non-cirrhotic portal hypertension to cirrhosis was documented. In spite of the cessation of pharmaceutical vitamin A intake, the disease progressed. Therapy with colchicine and phenobarbital apparently did not influence evolution to cirrhosis. This suggests that vitamin A can trigger largely unknown mechanisms of liver fibrosis which seem to be self-perpetuating.
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Handle