|
Title
|
|
|
|
Vitamin A abuse : development of cirrhosis despite cessation of vitamin A : a six year clinical and histologic follow-up
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| We report the case of a 35-year-old man who contracted vitamin A-induced liver cirrhosis. Five years before, he had been investigated for vitamin A-induced non-cirrhotic portal hypertension. In this case, the clinical and histopathologic evolution from non-cirrhotic portal hypertension to cirrhosis was documented. In spite of the cessation of pharmaceutical vitamin A intake, the disease progressed. Therapy with colchicine and phenobarbital apparently did not influence evolution to cirrhosis. This suggests that vitamin A can trigger largely unknown mechanisms of liver fibrosis which seem to be self-perpetuating. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Liver. - -
| |
|
Publication
|
|
|
|
1992
| |
|
ISSN
|
|
|
|
0106-9543
| |
|
Volume/pages
|
|
|
|
12
:6
(1992)
, p. 381-386
| |
|
ISI
|
|
|
|
A1992KF87300004
| |
|