Title Proton relaxation enhancement by means of serum albumine and poly-L-lysine labeled with $DTPA-Gd^{3+}$ : relaxivities as function of molecular weight and conjugation efficiency Author Spanoghe, M. Lanens, D. Dommisse, R. Van Der Linden, A. Alderweireldt, F. Faculty/Department Faculty of Sciences. Chemistry Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences Publication type article Publication 1992 New York , 1992 Subject Computer. Automation Source (journal) Magnetic resonance imaging. - New York Volume/pages 10(1992) :6 , p. 913-917 ISSN 0730-725X ISI A1992JZ77200007 Carrier E Target language English (eng) Full text (Publishers DOI) Affiliation University of Antwerp Abstract A series of poly-L-lysine chains, with molecular weight ranging from 3300 up to 102,000 Da, were labeled with DTPA-Gd3+. No significant differences in longitudinal and transversal relaxivity, could be demonstrated as a function of the chain length. The R1 and R2 relaxivities were respectively 2.5 and 5 times superior to those of plain DTPA-Gd3+ (at 2.4 T). Bovine serum albumin was also labeled in a way that a wide (DTPA-Gd3+)/BSA range (3-39) was obtained. The longitudinal relaxivity, of these paramagnetically labeled albumins, increased with increasing (DTPA-Gd3+)/BSA ratios. This effect was most pronounced at very low (DTPA-Gd3+)/BSA ratios. E-info https://repository.uantwerpen.be/docman/iruaauth/1527aa/51b4149.pdf http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992JZ77200007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992JZ77200007&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848 Handle