Title
Proton relaxation enhancement by means of serum albumine and poly-L-lysine labeled with <tex>$DTPA-Gd^{3+}$</tex> : relaxivities as function of molecular weight and conjugation efficiency Proton relaxation enhancement by means of serum albumine and poly-L-lysine labeled with <tex>$DTPA-Gd^{3+}$</tex> : relaxivities as function of molecular weight and conjugation efficiency
Author
Faculty/Department
Faculty of Sciences. Chemistry
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
New York ,
Subject
Computer. Automation
Source (journal)
Magnetic resonance imaging. - New York
Volume/pages
10(1992) :6 , p. 913-917
ISSN
0730-725X
ISI
A1992JZ77200007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
A series of poly-L-lysine chains, with molecular weight ranging from 3300 up to 102,000 Da, were labeled with DTPA-Gd3+. No significant differences in longitudinal and transversal relaxivity, could be demonstrated as a function of the chain length. The R1 and R2 relaxivities were respectively 2.5 and 5 times superior to those of plain DTPA-Gd3+ (at 2.4 T). Bovine serum albumin was also labeled in a way that a wide (DTPA-Gd3+)/BSA range (3-39) was obtained. The longitudinal relaxivity, of these paramagnetically labeled albumins, increased with increasing (DTPA-Gd3+)/BSA ratios. This effect was most pronounced at very low (DTPA-Gd3+)/BSA ratios.
E-info
https://repository.uantwerpen.be/docman/iruaauth/1527aa/51b4149.pdf
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