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Title
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Proton relaxation enhancement by means of serum albumine and poly-L-lysine labeled with : relaxivities as function of molecular weight and conjugation efficiency
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Author
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Abstract
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| A series of poly-L-lysine chains, with molecular weight ranging from 3300 up to 102,000 Da, were labeled with DTPA-Gd3+. No significant differences in longitudinal and transversal relaxivity, could be demonstrated as a function of the chain length. The R1 and R2 relaxivities were respectively 2.5 and 5 times superior to those of plain DTPA-Gd3+ (at 2.4 T). Bovine serum albumin was also labeled in a way that a wide (DTPA-Gd3+)/BSA range (3-39) was obtained. The longitudinal relaxivity, of these paramagnetically labeled albumins, increased with increasing (DTPA-Gd3+)/BSA ratios. This effect was most pronounced at very low (DTPA-Gd3+)/BSA ratios. |
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Language
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English
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Source (journal)
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Magnetic resonance imaging. - New York
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Publication
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New York
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1992
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ISSN
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0730-725X
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DOI
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10.1016/0730-725X(92)90445-6
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Volume/pages
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10
:6
(1992)
, p. 913-917
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ISI
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A1992JZ77200007
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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