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Title
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PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease
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Author
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Abstract
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| We analyzed the PRNP M129V polymorphism in a Dutch population-based early-onset Alzheimer's disease sample. We observed a significant association between early-onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1-3.3; P = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively. |
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Language
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English
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Source (journal)
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Annals of neurology. - Boston, Mass.
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Publication
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Boston, Mass.
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2003
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ISSN
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0364-5134
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DOI
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10.1002/ANA.10507
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Volume/pages
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53
:3
(2003)
, p. 409-412
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ISI
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000181200400019
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Full text (Publisher's DOI)
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