Augmented monocytic proinflammatory cytokines in acute coronary syndromes: relation with plaque inflammation and rupture, and with neointimal thickening
Faculty of Sciences. Physics
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Bologna :Monduzzi, 2002
Atherosclerosis: risk factors, diagnosis, and treatment / Kostner, G.E. [edit.]
University of Antwerp
We evaluated the relation of cytokine levels (both in serum and in cytoplasm of circulating monocytes and lymphocytes) with atherosclerotic plaque inflammation and rupture, and with neointimal formation after stent implantation. In contrast to serum cytokines, the cumulative stimulated cytoplasmatic concentration of IL-1beta, IL-6 and TNF-alpha in circulating monocytes of patients with UA is significantly related to the extent of macrophage infiltration and plaque rupture, and strongly related to the final amount of in-stent neointimal proliferation.