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Title
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Augmented monocytic proinflammatory cytokines in acute coronary syndromes: relation with plaque inflammation and rupture, and with neointimal thickening
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Author
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Abstract
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| We evaluated the relation of cytokine levels (both in serum and in cytoplasm of circulating monocytes and lymphocytes) with atherosclerotic plaque inflammation and rupture, and with neointimal formation after stent implantation. In contrast to serum cytokines, the cumulative stimulated cytoplasmatic concentration of IL-1beta, IL-6 and TNF-alpha in circulating monocytes of patients with UA is significantly related to the extent of macrophage infiltration and plaque rupture, and strongly related to the final amount of in-stent neointimal proliferation. |
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Language
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English
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Source (book)
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Atherosclerosis: risk factors, diagnosis, and treatment / Kostner, G.E. [edit.]
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Publication
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Bologna
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Monduzzi
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2002
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ISBN
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88-323-2707-4
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Volume/pages
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p. 399-404
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ISI
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000178569900075
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