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Title
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Dose dependent effect of APOE ε4 on behavioral symptoms in frontal lobe dementia
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Author
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Abstract
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| To determine whether apolipoprotein alleles (APOE) influence behavioral and psychological signs and symptoms of dementia (BPSD), we initiated a prospective, longitudinal study. Patients with Alzheimer's disease (AD) (N = 186), frontotemporal dementia (FTD) (N=29), mixed dementia (MXD) (N= 28), dementia with Lewy bodies (DLB) (N= 11) and Parkinson's disease dementia (PDD) (N = 7) were included. Blood was collected for DNA extraction and APOE genotyping. Behavioral assessments were performed at baseline and semi-annually thereafter, using behavioral assessment scales (Middelheim frontality score, behavioral pathology in Alzheimer's disease rating scale (Behave-AD)). In FTD patients, we identified close dependent effects of APOE epsilon 4 on the Behave-AD total and cluster aggressiveness scores. APOE epsilon 2 was associated with a higher score on the Behave-AD cluster delusions in PDD/DLB patients. No APOE effects on frequency or severity of BPSD in AD and MXD Patients Were found. In Conclusion, APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE epsilon 4 with aggression (FTD) and of APOE epsilon 2 with delusions (PDD/DLB). (C) 2005 Elsevier Inc. All rights reserved. |
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Language
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English
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Source (journal)
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Neurobiology of aging. - Fayetteville, N.Y.
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Publication
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Fayetteville, N.Y.
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2006
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ISSN
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0197-4580
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DOI
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10.1016/J.NEUROBIOLAGING.2005.02.005
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Volume/pages
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27
:2
(2006)
, p. 285-292
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ISI
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000234782400012
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Full text (Publisher's DOI)
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