Publication
Title
Effect of ageing and malnutrition on rat myocardium : part 2 : the microvasculature
Author
Abstract
The modulating effects of ageing and malnutrition on rat myocardium were studied morphometrically with respect to the microvasculature. An increase in capillary density together with a decrease in capillary lumen cross-sectional area was noted during starvation. The important changes seen in the myocyte T-system were paralleled by a decreased diffusion distance for oxygen from the capillary lumen to the mitochondrion. The changes described in the aged rat heart point to an altered inter-relationship between parenchyma and vascularization with a lower capillary volume fraction and a greater diffusion distance from the capillary lumen to the mitochondrion; this is caused by hypertrophy of the aged myocyte. This reduction in capacity to exchange substrates is further reduced by the less developed T-system in the older myocyte.
Language
English
Source (journal)
Virchows Archiv: A: pathological anatomy and histopathology. - Berlin, 1974 - 1993
Publication
Berlin : 1992
ISSN
0174-7398
Volume/pages
421(1992), p. 189-192
ISI
A1992JP43800002
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.10.2008
Last edited 13.06.2017
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