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Title
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Effect of ageing and malnutrition on rat myocardium : part 2 : the microvasculature
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Author
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Abstract
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| The modulating effects of ageing and malnutrition on rat myocardium were studied morphometrically with respect to the microvasculature. An increase in capillary density together with a decrease in capillary lumen cross-sectional area was noted during starvation. The important changes seen in the myocyte T-system were paralleled by a decreased diffusion distance for oxygen from the capillary lumen to the mitochondrion. The changes described in the aged rat heart point to an altered inter-relationship between parenchyma and vascularization with a lower capillary volume fraction and a greater diffusion distance from the capillary lumen to the mitochondrion; this is caused by hypertrophy of the aged myocyte. This reduction in capacity to exchange substrates is further reduced by the less developed T-system in the older myocyte. |
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Language
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English
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Source (journal)
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Virchows Archiv: A: pathological anatomy and histopathology. - Berlin, 1974 - 1993
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Publication
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Berlin
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1992
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ISSN
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0174-7398
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DOI
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10.1007/BF01611174
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Volume/pages
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421
(1992)
, p. 189-192
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ISI
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A1992JP43800002
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Full text (Publisher's DOI)
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