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Title
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**DNMBP** is genetically associated with Alzheimer dementia in the Belgian population
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Author
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Abstract
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| Genetic association of the dynamin binding protein gene (DNMBP) on chromosome 10 with late-onset Alzheimer's disease (AD) was reported among Japanese. Here, we assessed the genetic role of DNMBP in an extended Belgian AD group using a gene-wide association approach. A total of 18 SNPs across the DNMBP locus were genotyped in 555 late-onset AD patients and 638 healthy control individuals. Significant associations were observed for two SNPs (rs3740057 and rs10883421). Haplotype analysis identified association with haplotype blocks in the 3 region of DNMBP comprising rs2862919, rs11190302, rs10509739, rs2256700 and comprising rs3740057 and rs6584331. Stratification for APOE 4 status showed that association was only present in the APOE 4 negative subgroup. Sliding-window analyses provided further evidence for association with the 3end of DNMBP both for the total and for the APOE 4 negative group. Taken together our findings underscore a role for DNMBP in the genetic risk for late-onset AD in the Belgian population. |
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Language
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English
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Source (journal)
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Neurobiology of aging. - Fayetteville, N.Y.
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Publication
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Fayetteville, N.Y.
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2009
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ISSN
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0197-4580
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DOI
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10.1016/J.NEUROBIOLAGING.2008.02.003
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Volume/pages
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30
:12
(2009)
, p. 2000-2009
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ISI
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000271252200012
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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