Title
Evidence for circulating activated cytotoxic T cells in HIV-infected subjects before the onset of opportunistic infectionsEvidence for circulating activated cytotoxic T cells in HIV-infected subjects before the onset of opportunistic infections
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Research group
Laboratory for Microbiology, Parasitology and Hygiene (LMPH)
Epidemiology and social medicine (ESOC)
Publication type
article
Publication
Oxford,
Source (journal)
Clinical and experimental immunology. - Oxford
Volume/pages
82(1990), p. 3-9
ISSN
0009-9104
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
The activity ofboih cytoloxic T lymphocyte (CTL) and natural killer (NK) cells were measured crosssectionally in 43 subjects seropositive for HIV. in 27 HIV blood donors and in 24 HIV persons from the Outpatients Clinic for se,\ually transmitted diseases. CTL activity was evaluated using the HL-60 cells coated with 0KT3 as the targets and freshly separated peripheral blood lymphocytes as theelfectors. In 20 out of43 H IV subjeets, CTL aetivity was significantly enhanced in comparison to the HIV subjects. This lytic activity correlated positively with the percentages of CD3 ' HLA-DR \ of CD8
Handle