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Title
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Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
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Author
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Abstract
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| The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there are no consensus case definitions for IRIS or tuberculosis-associated IRIS. Moreover, previously proposed case definitions are not readily applicable in settings where laboratory resources are limited. As a result, existing studies on tuberculosis-associated IRIS have used a variety of non-standardised general case definitions. To rectify this problem, around 100 researchers, including microbiologists, immunologists, clinicians, epidemiologists, clinical trialists, and public-health specialists from 16 countries met in Kampala, Uganda, in November, 2006. At this meeting, consensus case definitions for paradoxical tuberculosis-associated IRIS, ART-associated tuberculosis, and unmasking tuberculosis-associated IRIS were derived, which can be used in high-income and resource-limited settings. It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data. |
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Language
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English
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Source (journal)
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The lancet infectious diseases. - London
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Publication
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London
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2008
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ISSN
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1473-3099
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DOI
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10.1016/S1473-3099(08)70184-1
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Volume/pages
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8
:8
(2008)
, p. 516-523
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ISI
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000258024800021
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Full text (Publisher's DOI)
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