Title
Microsatellite instability in sporadic colon carcinomas has no independent prognostic value in a Belgian study populationMicrosatellite instability in sporadic colon carcinomas has no independent prognostic value in a Belgian study population
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Anatomopathologie
Medical Genetics (MEDGEN)
Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
Epidemiology and social medicine (ESOC)
Publication type
article
Publication
Oxford,
Subject
Human medicine
Source (journal)
European journal of cancer. - Oxford, 1990, currens
Volume/pages
44(2008):15, p. 2288-2295
ISSN
0959-8049
ISI
000261020800028
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Pathological stage is currently the most important determinant of colorectal cancer prognosis. Hence, identification of additional prognostic markers is warranted. This study aimed to analyse the prognostic relevance of microsatellite instability (MSI) in 241 colon and 90 rectal tumours, using a mononucleotide loci multiplex PCR assay and immunohistochemistry. Thirty (12.4%) colon tumours and one rectal tumour showed MSI. Although MSI was associated with proximal location and poor differentiation, no survival benefit was observed. The prognostic value of stage and differentiation was confirmed in this study. Analysis by stage revealed a longer overall (stage II/III) and disease free survival (stage II) for patients with well differentiated tumours. In addition, age and distal localisation were related to longer overall survival in stage II tumours. In conclusion, our findings show an association of MSI in sporadic colon tumours and certain clinical features; however, they do not suggest a survival benefit for MSI tumours.
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