Title
Interspecies recombination occurs frequently in quinolone resistance-determining regions of clinical isolates of **Streptococcus pyogenes**Interspecies recombination occurs frequently in quinolone resistance-determining regions of clinical isolates of **Streptococcus pyogenes**
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Publication type
article
Publication
Washington, D.C.,
Subject
Human medicine
Source (journal)
Antimicrobial agents and chemotherapy. - Washington, D.C.
Volume/pages
52(2008):11, p. 4191-4193
ISSN
0066-4804
ISI
000260305600058
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Fluoroquinolone resistance in Streptococcus pyogenes has been reported only anecdotally, but a recent Belgian surveillance study found a rate of nonsusceptibility of 5.4%. From an analysis of these isolates, we show that interspecies horizontal gene transfer within the parC quinolone resistance-determining region is a frequent phenomenon that might contribute to fluoroquinolone resistance.
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