Recente verbeteringen in de inductiechemotherapie van locoregionaal gevorderde hoofd-halstumoren
Faculty of Medicine and Health Sciences
Nederlands tijdschrift voor oncologie. - Amsterdam, 2004, currens
, p. 358-365
University of Antwerp
Treatment strategy in patients with locoregionally advanced head and neck cancer has gradually evolved into one that is based upon radiotherapy and chemotherapy. In this setting, induction chemotherapy with cisplatin and 5-fluorouracil, followed by locoregional treatment with (chemo)-radiotherapy, has proven to be a valuable option.Several randomised trials have shown that the addition of a taxane to the cisplatin/5-fluorouracil-scheme is feasible and enhances efficacy. This has been demonstrated in particular for docetaxel. In patients with ocoregionally advanced head and neck cancer qualifying for induction chemotherapy, the docetaxel/cisplatin/5-fluorouracil should be considered as the new standard.