Publication
Title
Virulence characteristics of Klebsiella and clinical manifestations of **K. pneumoniae** bloodstream infections
Author
Abstract
We studied 455 consecutive episodes of Klebsiella pneumoniae bacteremia occurring in 7 countries. Community-acquired pneumonia and an invasive syndrome of liver abscess, meningitis, or endophthalmitis occurred only in Taiwan and South Africa. Infections by K1 and K2 capsular serotype, the mucoid phenotype, and aerobactin production were important determinants of virulence. The mucoid phenotype was seen in 94% of isolates in patients with community-acquired pneumonia and in 100% of isolates that caused the invasive syndrome in Taiwan and South Africa, compared with only 2% of isolates elsewhere. Mortality of mice injected with mucoid strains (69%) was strikingly higher than that occurring in mice injected with nonmucoid strains (3%, p<0.001). Differences in clinical features of bacteremic infection with K. pneumoniae are due to the virulence factors expressed by the organism.
Language
English
Source (journal)
Emerging infectious diseases / National Center for Infectious Diseases. Centers for Disease Control and Prevention. - Atlanta, Ga
Publication
Atlanta, Ga : 2007
ISSN
1080-6040
Volume/pages
13:7(2007), p. 986-993
ISI
000247758200004
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 13.01.2009
Last edited 16.05.2017
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