Title
A potential virulence gene, <tex>$hyl_{Efm}$</tex>, predominates in **Enterococcus faecium** of clinical origin A potential virulence gene, <tex>$hyl_{Efm}$</tex>, predominates in **Enterococcus faecium** of clinical origin
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Chicago, Ill. ,
Subject
Human medicine
Source (journal)
The journal of infectious diseases. - Chicago, Ill.
Volume/pages
187(2003) :3 , p. 508-512
ISSN
0022-1899
ISI
000180636800021
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
An open reading frame (hyl[SUBEfm]) with homologies to previously described hyaluronidase genes has been identified in nonstool isolates of Enterococcus faecium. E. faecium isolates (n = 577) from diverse sources were screened for the presence of and hyl[SUBEfm] and esp[SUBEfm], a putative virulence gene associated with epidemic E. faecium strains. The presence of esp[SUBEfm] was roughly twice that of hyl[SUBEfm] but both were found primarily in vancomycin-resistant E. faecium isolates in nonstool cultures obtained from patients hospitalized in the United States. These data suggest that specific E. faecium strains may be enriched in determinants that make them more likely to cause clinical infections. Differences in the prevalence of these strains may help explain variations in the clinical importance of multi-resistant E. faecium across different continents.
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