Title
Contact patterns and their implied basic reproductive numbers: an illustration for varicella-zoster virus
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
Epidemiology and infection. - London, 1987, currens
Volume/pages
137(2009) :1 , p. 48-57
ISSN
0950-2688
1469-4409
ISI
000262067800005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The WAIFW matrix (Who Acquires Infection From Whom) is a central parameter in modelling the spread of infectious diseases. The calculation of the basic reproductive number (R0) depends on the assumptions made about the transmission within and between age groups through the structure of the WAIFW matrix and different structures might lead to different estimates for R0 and hence different estimates for the minimal immunization coverage needed for the elimination of the infection in the population. In this paper, we estimate R0 for varicella in Belgium. The force of infection is estimated from seroprevalence data using fractional polynomials and we show how the estimate of R0 is heavily influenced by the structure of the WAIFW matrix.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/2e4628/911839f7.pdf
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