Title
Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of **Pseudomonas aeruginosa** Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of **Pseudomonas aeruginosa**
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Washington, D.C. ,
Subject
Biology
Human medicine
Source (journal)
Antimicrobial agents and chemotherapy. - Washington, D.C.
Volume/pages
52(2008) :3 , p. 1173-1175
ISSN
0066-4804
ISI
000253553500055
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In a university hospital, time-series analysis revealed a significant relationship between antibiotic (aminoglycoside, fluoroquinolone, and cefepime) use and incidence of MexXY-OprM-overproducing Pseudomonas aeruginosa. In vitro experiments confirm that such mutants were readily selected from both PAO1 and clinical strains when grown in the presence of these antibiotics.
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