Title
Recommendations for the treatment of epilepsies in general practice in Belgium Recommendations for the treatment of epilepsies in general practice in Belgium
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Bruxelles ,
Subject
Human medicine
Source (journal)
Acta neurologica Belgica. - Bruxelles
Volume/pages
108(2008) :4 , p. 118-130
ISSN
0300-9009
2240-2993
ISI
000263358900002
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
The large choice of antiepileptic drugs (AEDs) in Belgium complicates the selection of the appropriate product for the individual patient. International guidelines on the treatment of epilepsy have been published, but are not tailored to the Belgian situation. This publication presents recommendations from a group of Belgian epilepsy experts for the practical management of epilepsy in general practice in Belgium. It includes recommendations for initial monotherapy and add-on treatment in adult patients (> 16 years) and initial monotherapy in paediatric patients (< 16 years). For these three situations a first choice AED is recom mended. One or more alternative first choice AEDs are defined for patients in which certain patient- or AED-related factors preclude the use of the first choice product. Selection of compounds was based on the registration and reimbursement status in Belgium, the level of evidence of efficacy, common daily practice and the personal views and experiences of the authors. The paper reflects the situation in 2008. In addition to the treatment recommendations, other relevant points to consider in the treatment of epilepsy with AEDs are addressed, including comorbidity and age of the patient, the interaction potential, pharmacokinetic properties and safety profile of the AEDs, and generic substitution.
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