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Title
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Comparing the cost effectiveness of risperidone and olanzapine in the treatment of schizophrenia using the net-benefit regression approach
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Author
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Abstract
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| Objective To estimate the cost effectiveness of olanzapine and risperidone for the treatment of schizophrenia in Belgium. Methods Data were retrieved from a prospective, observational, non-randomized, follow-up survey. Clinical investigators assigned 265 patients with schizophrenia to either olanzapine (n = 136) or risperidone (n = 129). Patients were followed up for 2 years. Total healthcare costs were determined from the public payer perspective and calculated by multiplying resource use with official tariffs; effectiveness of the drugs was measured with the EQ-5D. This study uses a net-benefit regression approach to accommodate for baseline differences between treatment groups and uncertainty. Results Total 2-year costs were very similar for patients receiving risperidone and olanzapine (20 915.33 and 20 569.69, respectively; p = 0.925) [year 2002 values]. The health condition of the patients receiving risperidone was better than that of patients receiving olanzapine but not significantly so (1.46 and 1.41, respectively; p = 0.191). Simple ordinary least squares (OLS) regressions indicated that, for ë = 40 000, we could not reject the null hypothesis that the drugs provide similar net monetary benefits to the patient (risperidone vs olanzapine 2046.95; p = 0.656). When we controlled for several patient characteristics, risperidone moved further away from olanzapine but the difference did not reach statistical significance (risperidone vs olanzapine 3198.07; p = 0.595). Numerous sensitivity analyses confirmed the robustness of the results. Conclusion Results of this study suggest that it is important to control for baseline patient characteristics when performing a cost-effectiveness analysis. No significant difference in net monetary benefit was found between risperidone and olanzapine. |
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Language
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English
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Source (journal)
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Pharmacoeconomics. - Auckland, 1998 - 2015
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Publication
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Auckland
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2009
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ISSN
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1170-7690
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DOI
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10.2165/00019053-200927010-00007
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Volume/pages
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27
:1
(2009)
, p. 69-80
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ISI
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000264273000007
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Full text (Publisher's DOI)
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