Title
Effect of clinical and probiotic **Lactobacillus rhamnosus** strains on intestinal permeability and bacterial translocation in healthy and colitic rats Effect of clinical and probiotic **Lactobacillus rhamnosus** strains on intestinal permeability and bacterial translocation in healthy and colitic rats
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Ottawa ,
Subject
Veterinary medicine
Source (journal)
Food research international / Canadian Institute of Food Science and Technology. - Ottawa
Volume/pages
42(2009) :5/6 , p. 636-640
ISSN
0963-9969
ISI
000266765500011
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Lactobacillus rhamnosus is one of the most widely used probiotic microorganisms. Although this microorganism is not known for its virulence some rare cases of bacteraemia and endocarditis have been observed. Thus, it is important to identify the possible risks associated with each strain. Comparison of clinical and probiotic strains may give information on properties that could be a safety concern. A possible adverse effect is bacterial translocation. Animals with induced colitis constitute a good model to assess translocation in the case of mucosal barrier disruption. We aimed at determining the ability of five L. rhamnosus strains, from clinical or probiotic origin, showing different in vitro properties, to induce in vivo translocation in both, healthy and colitic animals. We also tested the effects on the gut mucosal lining by measuring intestinal permeability. None of the in vitro parameters used for selection of the strains included in this study appear to be a risk for translocation or mucosal barrier disruption.
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