Title
Evaluation and determination of reference intervals of the C-peptide assay on Elecsys 2010®
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Paris ,
Subject
Pharmacology. Therapy
Source (journal)
Immuno-analyse et biologie specialisée. - Paris
Volume/pages
23(2008) :5 , p. 286-288
ISSN
0923-2532
ISI
000261009900004
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
C-peptide is a single chain peptide with a molecular mass of approximately 3600 kDa. As a split-off product during insulin secretion, C-peptide enters the circulation in equimolar amounts with insulin. Measurement of serum C-peptide concentrations, both fasting or as a part of functional tests, is useful to assess pancreatic â-cell function and to estimate the amount of residual insulin secretion in insulin dependent (type-I) diabetes mellitus. For the correct interpretation of patient results, the availability of a healthy population-based reference interval is essential. The aim of this study was to determine the reference interval of the Elecsys 2010 C-peptide assay in a healthy adults.
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Handle