Evaluation and determination of reference intervals of the C-peptide assay on Elecsys 2010®
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Immuno-analyse et biologie specialisée. - Paris
, p. 286-288
University of Antwerp
C-peptide is a single chain peptide with a molecular mass of approximately 3600 kDa. As a split-off product during insulin secretion, C-peptide enters the circulation in equimolar amounts with insulin. Measurement of serum C-peptide concentrations, both fasting or as a part of functional tests, is useful to assess pancreatic â-cell function and to estimate the amount of residual insulin secretion in insulin dependent (type-I) diabetes mellitus. For the correct interpretation of patient results, the availability of a healthy population-based reference interval is essential. The aim of this study was to determine the reference interval of the Elecsys 2010 C-peptide assay in a healthy adults.